Перегляд за автором "Yarmoluk, S.M."

Результати 1-20 з 20

Antiproliferative activities of some 7-hydroxy-3-aryloxy-2-trifluoromethyl-4H-4-chromenone derivatives against 60 human cancer cell lines

Prykhod'ko, A.O.; Dubinina, G.G.; Khilya, V.P.; Yarmoluk, S.M. (Біополімери і клітина, 2004)

234 derivatives of 7-hydroxy-3-aryloxy-2-trifluoromethyl-4H-4-chromenones were synthesized and tested for antitumor activity in vitro against human cancer cell lines in NCI (National Cancer Institute, USA) bioassay. It was ...
Application of MALDI-TOF mass spectrometry for study on fibrillar and oligomeric aggregates of alpha-synuclein

Severinovskaya, O.V.; Kovalska, V.B.; Losytskyy, M.Yu.; Cherepanov, V.V.; Subramaniam, V.; Yarmoluk, S.M. (Вiopolymers and Cell, 2014)

Aim. To study the -synuclein (ASN) aggregates of different structural origin, namely amyloid fibrils and spherical oligomers, in comparison with a native protein. Methods. MALDI TOF mass spectrometry and atomic for- ce ...
Design of 4-(4-dialkylaminostyryl) -pyridinium dyes for fluorescent detection of amyloid fibrils

Inshyn, D.I.; Chernii, S.V.; Kovalska, V.B.; Yarmoluk, S.M. (Вiopolymers and Cell, 2016)

The pathological proteins aggregation into the fibrillar structures is common to a large group of amyloid-related disorders, such as neurodegenerative diseases. Accordingly, there is a need for development of analytical ...
Evaluation of 4H-4-chromenone derivatives as inhibitors of protein kinase CK2

Prykhodko, A.O.; Yakovenko, O.Ya.; Golub, A.G.; Bdzhola, V.G.; Yarmoluk, S.M. (Біополімери і клітина, 2005)

Protein kinase CK2 (Casein Kinase 2) is a ubiquitous serine/threonine protein kinase involved in various cell signal transduction pathways. Thus, CK2 is a new perspective target for anticancer drugs. The receptor-based ...
Hit identification of CK2 inhibitors by virtual screening

Protopopov, M.V.; Starosyla, S.A.; Borovykov, O.V.; Sapelkin, V.N.; Bilokin, Y.V.; Bdzhola, V.G.; Yarmoluk, S.M. (Вiopolymers and Cell, 2017)

Aim. To search for new CK2 inhibitors by virtual screening. Methods. Virtual screening of a small organic compounds library was performed by molecular docking using the Autodock 4.2.6 package and pharmacophore screening ...
Hit identification of FGFR1 inhibitors using receptor-based virtual screening

Tarnavskiy, S.S.; Protopopov, M.V.; Borovykov, O.V.; Pryhodko, A.O.; Bdzhola, V.G.; Yarmoluk, S.M. (Вiopolymers and Cell, 2019)

Aim. To identify novel FGFR1 inhibitors using the virtual screening approach. Methods. Virtual screening of a small organic compounds library was performed by molecular docking using the Autodock 4.2.6 program package. The ...
Identification of 4‐methoxythieno[2,3‐d]pyrimidines as FGFR1 Inhibitors

Kotey, I.M.; Protopopov, M.V.; Starosyla, S.A.; Balanda, A.O.; Pletnova, L.V.; Prykhod'ko, A.O.; Bdzhola, V.G.; Yarmoluk, S.M. (Вiopolymers and Cell, 2019)

Aim. To identify novel FGFR1 inhibitors using virtual screening approach. Methods. We used methods of organic synthesis, molecular docking via the Autodock 4.2.6 program package and in vitro biochemical tests with γ-32P. ...
Interaction of cyanine dyes with nucleic acids. 2. Spectroscopic properties of methyleneoxy analogues of Thiazole Orange

Yarmoluk, S.M.; Kovalska, V.B.; Smirnova, T.V.; Shandura, M.P.; Kovtun, Y.P.; Matsuka, G.K. (Биополимеры и клетка, 1996)

A series of asymmetric cyanine dyes based on methylenoxy benzothiazole terminal hetero-cycle was synthesized. Absorption and fluorescent properties of these dyes and their complexes with nucleic acids were investigated. ...
Interaction of cyanine dyes with nucleic acids. 3. The of new cyanine dyes Cyan 13 and Cyan 40 for detection of nucleic acids in agarose gel

Yarmoluk, S.M.; Dubey, I.Y. (Биополимеры и клетка, 1997)

Detection of double-stranded DNA (dsDNA) and single-strended DNA (ssDNA) and RNA with two new cyanine dyes Cyan 13 and Cyan 40 is reported. Cyan 13 and Cyan. 40 bind to nucleic acids to form a stable fluorescent complexes ...
Interaction of cyanine dyes with nucleic acids. 4. Efficient 5-fluorescent labelling of oligonucleotides with monomethyne pyrylium cyanine dye, Cyan 39

Yarmoluk, S.M.; Kostenko, A.M.; Kornushyna, O.S.; Dubey, I.Y. (Биополимеры и клетка, 1998)

A new system for fluorescent 5'-end labelling of oligonucleotides with cyanine dyes is proposed. Reaction of primary amine with pyrylium salt was used for the efficient conjugation of monomethyne pyrylium cyanine dye with ...
Interaction of cyanine dyes with nucleic acids. 5. Towards model of «half intercalation» of monomethyne cyanine dyes into double-stranded nucleic acids

Yarmoluk, S.M.; Kovalska, V.B.; Kovtun, Y.P. (Биополимеры и клетка, 1999)

Recently we have proposed a model of "half intercalation" of monomethyne cyanine dye into the double-stranded helix. Benzothiazole terminal heterocycle «classically» intercalates, nestled between the adjacent base pairs ...
Interaction of cyanine dyes with nucleic acids. 6, Synthesis and spectroscopic properties of thiazole orange–amino acids conjugates

Yarmoluk, S.M.; Kryvorotenko, D.V.; Gerasymchuk, Y.S. (Биополимеры и клетка, 1999)

The synthesis of amino acid (L-Trp and L-Tyr) derivatives of thiazole orange, monomethirte cyanine dye which significantly increases fluorescence intensity when bound to nucleic acids is described. Hydroxysiiccinimsde ester ...
Interaction of cyanine dyes with nucleic acids. I. Studies on monomethyne cyanine dyes as possible fluorescent probes for the detection of nucleic acids

Yarmoluk, S.M.; Zhyvoloup, A.N.; Koval'ska, V.B.; Klimenko, I.V.; Kukharenko, A.P.; Kovtun, Y.P.; Slominsky, Y.I. (Биополимеры и клетка, 1996)

The series of monomethyne cyanine dyes as possible fluorescent probes for DNA and RNA analysis were synthesized and their optical properties were studied. Two dyes interacted with native DNA and RNA with strong fluorescence ...
MALDI mass spectrometry of zirconium and hafnium dibenzoylmethanate phthalocyanines

Chernii, V.Ya.; Severinovskaya, O.V.; Kovalska, V.B.; Tretyakova, I.N.; Losytskyy, M.Yu.; Yarmoluk, S.M.; Volkov, S.V. (Украинский химический журнал, 2012)

The GALDI mass spectrometry studies have shown the noticeable distinction in behavior of similar structure phthalocyanine complexes of zirconium and hafnium containing dibenzoylmethane groups as out-of-plane ligands. The ...
N-alkylaryl styrylcyanine dyes as fluorescent probes for nucleic acids detection

Kuperman, M.V.; Snihirova, Y.V.; Kryvorotenko, D.V.; Losytskyy, M.Yu.; Kovalska, V.B.; Yarmoluk, S.M. (Вiopolymers and Cell, 2018)

Aim. To synthesize and characterize a series of N-alkylaryl benzothiazole styrylcyanine dyes as potential ﬂuorescent probes for nucleic acids (NA) detection. Methods. Synthesis, absorption and fluorescence spectroscopy, ...
Nucleoside N-acylation with active derivatives of amino acids

Yarmoluk, S.M.; Kostenko, A.M.; Kryvorotenko, D.V.; Dubey, I.Y. (Биополимеры и клетка, 1996)

Simple procedure for N-acylation ofadenosine guanosine and cytidine by active derivatives of amino acids is proposed. Procedure is based on transient silyt protection ofribose hydroxy groups and consists of 3 steps: (a) ...
Rational design of protein kinase inhibitors

Yarmoluk, S.M.; Nyporko, A.Yu.; Bdzhola, V.G. (Вiopolymers and Cell, 2013)

Modern methodological approaches to rational design of low molecular weight compounds with specific activity in relation to predetermined biomolecular targets are considered by example of development of high effective ...
Strong enhancement of cyanine dye aggregation by a cationic surfactant

Guralchuk, G.Ya.; Katrunov, I.K.; Grinyov, R.S.; Sorokin, A.V.; Efimova, S.L.; Malyukin, Yu.V.; Yarmoluk, S.M. (Functional Materials, 2007)

Optical spectroscopy methods have been used to study the features of cyanine dye 3,3'-dimethyl-9-thienyl-thiacarbocyanine iodide (L-21) aggregation in the presence of cationic surfactant CPB at concentrations above the ...
Synthesis and biological evaluation of novel amino-substituted derivatives of pyrido[2,3-d]pyrimidine as inhibitors of protein kinase CK2

Zinchenko, A.N.; Muzychka, L.V.; Smolii, O.B.; Bdzhola, V.G.; Protopopov, M.V.; Yarmoluk, S.M. (Вiopolymers and Cell, 2017)

Aim. A search for human protein kinase CK2 inhibitors in a series of new amino-substituted pyrido[2,3-d]pyrimidine derivatives. Methods. Organic synthesis, analytical and spectral methods, molecular docking, in vitro ...
Towards the anti-fibrillogenic activity of phthalocyanines with out-of-plane ligands: correlation with self-association proneness

Kovalska, V.B.; Losytskyy, M.Yu.; Chernii, S.V.; Chernii, V.Ya.; Tretyakova, I.M.; Yarmoluk, S.M.; Volkov, S.V. (Вiopolymers and Cell, 2013)

Aim. The activity of five hafnium phthalocyanines containing out-of-plane ligands as inhibitors of reaction of insulin fibril formation is studied and correlation between their inhibitory properties and tendency to ...

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Перегляд за автором "Yarmoluk, S.M."

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